JPA (Java Persistence API) with Hibernate is a widely used combination for ORM in Java applications. Hibernate is an implementation of the JPA specification and provides a framework for mapping Java objects to relational databases. It simplifies database interaction and enhances the productivity of developers by automating tasks like object-relational mapping, query generation, and transaction management. Hibernate supports complex data models and provides advanced features like lazy loading and caching for better performance. It is frequently used in enterprise-level applications that require robust database integration and object-relational mapping.