iThenticate is a leading plagiarism detection tool specifically designed for academic publishers, researchers, and institutions. It compares submitted manuscripts against a vast database of academic papers, journal articles, books, and websites to identify similarities and potential instances of plagiarism. iThenticate is widely used by publishers, including Elsevier, Wiley, and Springer, as part of their submission process to ensure the originality of the content. Its importance in academic publishing lies in maintaining the ethical standards of scholarly work by ensuring that published research is original and properly cited. iThenticate provides detailed similarity reports, allowing editors and authors to review flagged content and make necessary corrections. It supports multiple languages and file formats, making it versatile for global academic use. By using iThenticate, journals and institutions can avoid publishing plagiarized work, thus maintaining the quality and integrity of the scholarly record. Its integration into manuscript submission systems helps streamline the review process by automating the plagiarism check.